As health systems worldwide confront rising life expectancy, increasing chronic disease burdens, and persistent health inequalities, the strategic enlargement of treatment-centric care with proactive prevention strategies has never been more urgent. Yet health outcomes are shaped not only by health systems, but also by social conditions, lifestyles, environments, and individual attitudes. The central challenge is therefore to embed prevention as a core engine within health systems and across society, driving better and more equitable outcomes for entire populations. By reframing prevention as a high value investment and leveraging innovation across sectors, including digital technologies, data driven approaches, and community-based strategies, societies can evolve toward models that promote vitality, resilience, and equity across the lifespan.