Karolina Jarosińska
Łukasz Indyka
The aim of the project was to create a focused library of compounds which would accelerate discovery of novel antiviral medicines, including drugs against SARS-CoV-2, HIV, HCV and other human health threatening viruses. The structures of the library members are unprecedented in the literature and have been designed based on the mechanism of the viral […]
Paweł Przewięźlikowski
Romaciclib (RVU120), a selective CDK8/19 inhibitor discovered at Ryvu Therapeutics in Kraków, is in development for AML, myelofibrosis, and low-risk MDS. Preclinical evidence and early clinical trials have demonstrated a favorable safety profile and signs of restored sensitivity to therapy (e.g., venetoclax in AML). With ongoing Phase II studies and a rapidly expanding clinical footprint, […]
Anna Bratek-Skicki
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) or Lou Gehrig’s disease, is a neurodegenerative disease that affects nerve cells in the brain and spinal cord. Nowadays, there is no treatment to reverse the damage of motor neurons or cure ALS. The disorders are characterized by the deposition of protein aggregates, which […]
Katarzyna Haraźna
Peripheral nerve damage can occur as a result of long-term inflammation or injury and can be very difficult to treat. In the United States, approximately half a million people suffer from this condition each year, resulting in operating costs exceeding $2 billion. Although surgeons often use autologous and allogeneic grafts to treat nerve damage, these […]
Dominika Träger
This work addresses the need for advanced implant materials that can support effective bone regeneration and integration with host tissue. While traditional ceramics are bioactive but brittle, polymers offer stability and processability without bioactivity. The planned approach is to combine the two to create a hybrid ceramic–polymer composite that combines structural durability with biological functionality. […]
Agnieszka Tomala
Load-bearing orthopaedic implants still fail due to fretting, wear debris, inflammation, and poor long-term osseointegration at the bone–implant interface, leading to costly, painful revision surgeries and reduced patient quality of life. The project develops a gradient biomaterial that combines cast titanium for toughness with an outer Titanium–hydroxyapatite (Ti/HAp) composite layer for osteoconductivity, further enhanced by […]
Jakub Gauza
Copper-64 is an emerging and versatile medical radioisotope with unique decay characteristics that enable its use in both diagnostic imaging and targeted radiotherapy. Due to its dual emission pathways (β⁺ for positron emission tomography – PET, and β⁻ for therapeutic applications), copper-64 provides a powerful theranostic platform, allowing simultaneous visualization of disease processes and targeted […]
Jacek Olczak
In early drug discovery, the transition from target identification to validated hit and lead series remains a critical bottleneck – particularly for complex targets such as under-characterized transmembrane receptors implicated in inflammation, fibrosis, and cancer. Fragmented outsourcing models and limited translational feedback between chemistry and biology teams often slow progress, inflate costs, and increase churn […]
Julia Kaniuka
We present here the design, development, and evaluation of an integrated actuator and measurement system based on a nitinol wire, which simultaneously serves as both an actuator and a sensing element. Leveraging the unique thermo-mechanical properties of shape-memory alloys, the system exploits the direct relationship between electrical resistance, displacement, and movement direction to estimate wire […]